About City of Hope

City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913,City of Hopehas grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis fornumerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilities in Atlanta, Chicago and Phoenix. City of Hope’s affiliated group of organizations includesTranslational Genomics Research InstituteandAccessHope^TM. For more information about City of Hope, follow us onFacebook,Twitter,YouTube,InstagramandLinkedIn.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

Dr. Alexey Danilov’s research is focused on the mechanisms of lymphomagenesis and identification of novel therapeutic targets in B-cell lymphoma and other cancers. Following our recent laboratory discoveries, we also explore the immunomodulatory effects of novel targeted agents and aim to harness their potential to enhance the efficacy of immunotherapy and novel cellular therapies.

We are looking for a Postdoc to advance one of the following areas of interest in our laboratory:

- immunomodulatory effects of targeted agents and mechanism-driven approaches to enhance efficacy of immune and cellular therapies;

- oncogenic mechanisms of transcriptional cyclin-dependent kinases.

Dr. Danilov's group coordinates a number of Phase I/II clinical trials, thus presenting an opportunity to verify the pre-clinical hypotheses in the clinical setting and conferring immediate relevance to pre-clinical investigations.

This position is created to continue research studies currently funded by the NCI R01, the Leukemia and Lymphoma Society Translational Research Program Award, MCL Research Initiative and Scholar Award. The project will match the candidate’s interests and experience.

Highly-motivated candidates with expertise in molecular biology, immunology, biochemistry and in vivo models who are interested in a career in oncology basic/translational research will be most competitive for this position.

The individual will be responsible for leading a collaborative research project focused on extrinsic mechanisms and drug resistance. Expertise with molecular biology and in vivo models will be required for this project. Additional responsibilities include but are not limited to: maintaining a high level of professional expertise in the field; supervising and providing guidance and mentorship to other researchers within the laboratory; designing and directing or executing experiments; and establishing laboratory procedures and systems that enforce and maintain a high level of organization in the lab. The individual should have demonstrated success in leading, managing and participating in collaborative projects and a distinguished record of scientific and technical accomplishments.

Basic education, experience and skills required for consideration:

The individual will have at least 3 years of post-graduate research experience in the relevant field. They are likely to have deep expertise in a singular area of focus but may also have worked as boundary spanners across multiple fields. Achieving this position requires that the researcher has demonstrated a satisfactory track record of scholarly activity including high-quality peer-reviewed publications. In order to maintain successful track record and show potential of growth, the individual must be actively engaged in publishing high-quality manuscripts, the development and submission of grant/funding proposals and leading projects that are aligned with the lab’s focus area.

Follows established City of Hope and department policies, procedures, objectives, performance improvement, attendance, safety, environmental, and infection control guidelines, including adherence to the workplace Code of Conduct and Compliance Plan. Practices a high level of integrity and honesty in maintaining confidentiality.

Performs other related duties as assigned or requested.

• Doctoral degree in relevant field and 3-5 years of relevant post-doctoral work experience. Fiveormoreyearsin aresearchposition,includingatleast 4yearsofsupervisoryandprojectmanagementexperience.
• Expertise in cancer biology, molecular/hematopoiesis, and genomics required. Experience with murine leukemia, hematopoiesis, and in FACS based methods, biochemistry, and molecular biology strongly preferred.
• Proficient with computers specifically MS Office (which includes, Excel, Access, Word, and PowerPoint) and statistical analysis software.
• Strong publication record
• Experience handling chemical and biologically hazardous materials.
• Knowledge of policy and regulations applicable to the laboratory, including but not limited to safety, animal, and radiation.
• Technical proficiency, scientific creativity collaborative ability, and independent thinker
• Experience with drug sensitivity/synergy analyses preferred.

Additional information:

• For more information about Dr. Danilov’s lab, please visit here.
• As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.